一、个人简介

冉杰，细胞生物学博士，山东师范大学教授，博士生导师，泰山学者青年专家，东岳学者拔尖人才。围绕“纤毛稳态调控及其生理病理功能”这一研究方向，阐明了多个纤毛关键蛋白在组织器官发育和人类重大疾病中的功能，并揭示了靶向纤毛及其关键蛋白在纤毛病中防治价值。相关成果以第一/通讯作者身份发表在Developmental Cell、Cell Death and Differentiation、Advance Science、Science Bulletin、Theranostics等主流期刊上。主持国家自然科学基金三项，省厅级项目三项，获得山东省自然科学二等奖一项。

二、研究方向

主要研究方向为：1）纤毛的动态调控网络；2）纤毛在组织器官发育和人类重大疾病发生发展中的功能及分子机制；3) 纤毛相关疾病治疗策略的开发与应用。

三、承担项目

1. 国家自然科学基金面上项目， 2022/01-2025/12，58万元，结题，主持。

2. 国家自然科学基金专项项目，2023/01-2025/12，63万元，结题，主持。

3. 泰山学者青年专家项目，2025/01-2027/12，75万元，在研，主持。

4. 山东省青年科学基金B类项目，2025/10-2028/09，50万元，在研，主持。

5. 国家自然科学基金青年项目, 2018/01-2020/12, 25万元,结题，主持。

6. 山东省高等学校青创团队计划，2023/01-2025/12，40万元，结题，主持。

三、代表性论文

1. Wang R, Guo G, Zhang R, Li L, Gong Y, Yin L, Li S, Wei C, Zhou J, Liu M*, Ran J*. UFL1-mediated UFMylation antagonizes IFT88 ubiquitination and degradation to maintain ciliary homeostasis. Cell Death and Differentiation 2026, 33(5): 1065-1080.

2. Guo G, Wang R, Zhang S, Zhang Y, Li L, Liu M, Yin L, Wei C, Gong Y, Jiao L, Li D, Zhou J, Liu M*, Ran J*. Preserving the UFMylation-cilium axis mitigates blue light-induced retinal degeneration. Journal of Molecular Cell Biology 2026. DOI: 10.1093/jmcb/mjag007.

3. Guo G, Li L, Zhou J*, Ran J*. Ciliary defects in inherited retinal diseases. Advanced Genetics 2026, 7(1): e00066.

4. Wang R, Zhang R, Zhou J*, Ran J*. Crosstalk between anti-angiogenic and pro-angiogenic pathways in disease: Mechanisms and therapeutic strategies. Pharmacology & Therapeutics 2025, 276: 108934.

5. Ran J*, Zhou J*. Post-translational modifications in cilia and ciliopathies. Advanced Science 2025, 12(31): e16562.

6. Song T, Han X, Yin H, Zhao J, Ma M, Wen X, Liu C, Yue Y, Zhao H, Zhou J, Yang Y, Ran J*, Liu M*. HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis. EMBO reports 2025, 26(10): 2597-2621.

7. Li L, Xie S, Zhou J*, Ran J*. Utilizing aptamers in targeted protein degradation strategies for disease therapy. The Journal of Pathology 2025, 266(2): 134-143

8. Li L, Zhou J*, Ran J*. Retinal photoreceptor cilia and ciliopathies: Molecular mechanisms and therapeutic strategies. Seminars in Cell & Developmental Biology 2025, 174: 103635.

9. Wang Z, Zhu X, Huang Z, Ren K, Ran J*, Yang Y*. Histone deacetylase 6 (HDAC6) in ciliopathies: Emerging insights and therapeutic implications. Advanced Science 2025, 12(21): e2412921.

10. Wang RN, Li L, Zhou J*, Ran J*. Multifaceted roles of UFMylation in health and disease. Acta Pharmacologica Sinica 2025, 46(4): 805-815.

11. Zhou P, Zhang S, Li L, Zhang R, Guo G, Zhang Y, Wang R, Liu M, Wang Z, Zhao H, Yang G, Xie S, Ran J*. Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis. Theranostics 2024, 14(13): 4983-5000.

12. Ran J, Guo G, Zhang S, Zhang Y, Zhang L, Li D, Wu S, Cong Y, Wang X, Xie S, Zhao H, Liu H, Ou G, Zhu X, Zhou J, Liu M*. KIF11 UFMylation maintains photoreceptor cilium integrity and retinal homeostasis. Advanced Science 2024, 11(25): e2400569.

13. Li L, Ran J*. Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins. Cell Death & Disease 2024, 15(1): 47.

14. Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, Xie S, Zhang X, Liu L, Liu M, Zhou J*. Targeting the HDAC6-cilium axis ameliorates the pathological changes associated with retinopathy of prematurity. Advanced Science 2022, 9(21): e2105365.

15. Ran J, Li H, Zhang Y, Yu F, Yang Y, Nie C, Yang S, Li D, Zhou J, Liu M*. A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling. Science Bulletin 2021, 66(16): 1620-1623.

16. Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J*. ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Developmental Cell 2020, 53(3): 287-299 e285.

四、获奖、专利等情况

1、 山东省自然科学二等奖

2、 授权国家发明专利3项

五、联系方式

山东师范大学（长清湖校区）博物楼，邮箱：jran@sdnu.edu.cn