王翊洁，教授，博士生导师。教育部海外引才计划项目获得者，山东省泰山学者青年专家，山东省海外优青

王翊洁教授长期致力于基因组稳定性维持的分子机制研究，重点关注其功能异常如何驱动肿瘤的发生与发展。实验室以DNA损伤应答与修复通路为核心研究方向，系统解析关键调控因子在不同遗传背景下的作用机制及其调控网络，旨在为合成致死靶策略的开发提供理潜在靶点与理论依据。近五年以第一或通讯作者身份在PNAS、Nature Communications、Advanced Science, Cancer Research、Oncogene等国际知名期刊发表SCI论文16篇；授权国家发明专利2项；参编中、英文论著各1部。

教育及工作经历

2007-2011 河南大学 学士

2011-2016 浙江大学 博士

2016-2021 美国西南医学中心 博士后

2021-至今 山东师范大学生命科学学院 教授

研究内容

1. 阐明基因组不稳定性与肿瘤发生发展的内在联系；

2. 构建DNA损伤修复的调控网络，揭示基因组稳定性维持的关键蛋白及其作用机制；

3. 基于合成致死原理，为开发肿瘤靶向治疗策略及增强放化疗敏感性提供新靶点。

承担项目

1. 国家自然科学基金面上项目，2026/01-2029/12，50万，主持

2. 教育部海外引才项目，2024/01-2026/12，90万，主持

3. 国家自然科学基金青年项目，2023/01-2025/12，30万，主持

4. 山东省泰山学者青年专家项目，2023/01-2025/12，75万，主持

5. 山东省海外优青项目，2022/04-2025/03，60万，主持

发表论文

1. Fei Meng^#, Yating Du^#, Junjie Liang^#, Huiyan Li, Jingjing Wang, Kexin Tang, Ruixue Kong, Huanran Sun, Tingting Yin, Junru Qin, Xiaomeng Yang, Changliang Shan, Min Liu, Guiwen Yang, Jichun Zhang, Yijie Wang^*, Jun Zhou^*, Yan Chen^*. The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis. Nature Communications. 2026; 17(1):614.

2. Miaomiao Zheng, Shuo Wang, Kexin Tang, Ruixue Kong, Xuemeng Wang, Jun Zhou, Yan Chen^*, Yijie Wang^*. The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells. PNAS. 2025; 122(1):e2413890121.

3. Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang^*, Jun Zhou^*, Yan Chen^*. NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression. Advanced Science. 2026; 13(5):e13380.

4. Huiyan Li^#, Fei Meng^#, Junjie Liang^#, Yijie Wang^*, Changliang Shan^*, Yan Chen^*. UFMylation System: Biological Functions, Molecular Mechanisms, Diseases, and Drug Discovery. Medcomm. 2025; 6(10):e70424.

5. Miaomiao Zheng, Jun Zhou^*, Yijie Wang^*. Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications. Cancer Biology & Medicine. 2025; 22(12):1455-1472.

6. Kexin Tang, Tingting Yin, Bo Deng, Min Wang, Zixuan Ren, Shuo Wang, Xiong Liu, Huiyan Li, Jingjing Wang, Yating Du, Jun Zhou, Yan Chen^*, Yijie Wang^*. USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion. Journal of Biological Chemistry. 2024; 300(9):107672.

7. Shuo Wang, Huiyan Li, Xiong Liu, Tingting Yin, Tingru Li, Miaomiao Zheng, Min Liu, Xiaoqian Meng, Jun Zhou, Yijie Wang^*, Yan Chen^*. VHL suppresses UBE3B-mediated breast tumor growth and metastasis. Cell Death & Disease. 2024; 15(6):446.

8. Yijie Wang^#, Xiong Liu^#, Min Wang, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen^*. UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation. Oncogene. 2023; 42(46):3394–3406.

9. Yijie Wang^#, Xiong Liu^#, Weixiao Huang^#, Junjie Liang, Yan Chen^*. The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic environment. Pharmacology & Therapeutics. 2022; 240:108303.

10. Weixiao Huang^#, Xiong Liu^#, Yao Zhang^#, Mingxia Deng, Guangqiang Li, Guo Chen, Li Yu, Lai Jin, Tongzheng Liu*, Yijie Wang^*, Yan Chen^*. USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α. Journal of Cellular Physiology. 2022; 237(4):2211-2219.

11. Yijie Wang, Yan Chen, Chenliang Wang, Mingming Yang, Yanan Wang, Lei Bao, Jennifer E. Wang, BongWoo Kim, Kara Y. Chen, Weizhi Xu, Emmanuela Capota, Janice Ortega, Deepak Nijhawan, Guo-min Li, Weibo Luo, Yingfei Wang^*. MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. Nature Communications. 2021; 12(1):2954.

12. Yijie Wang^#, Yan Chen^#, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang^*, Weibo Luo^*. CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors. Cancer Research. 2020; 80(18):3880-3891.

13. Yijie Wang^#, Guangqiang Li^#, Mingxia Deng, Xiong Liu, Weixiao Huang, Yao Zhang, Min Liu, Yan Chen^*. The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics. Pharmacology & Therapeutics. 2021; 221:107783.

14. Yan Chen^*, Min Liu, Yanling Niu, Yijie Wang^*. Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming. Cancer Letters. 2020; 495:211-223.

15. Yijie Wang, Weibo Luo*, Yingfei Wang^*. PARP-1 and its associated nucleases in DNA damage response. DNA Repair. 2019; 81:102651

16. Ji Cao^#, Yijie Wang^#, Rong Dong, Guanyu Lin, Ning Zhang, Jing Wang, Ling Ding, Qiaojun He, Bo Yang^*. Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells. Cancer Research. 2015; 75(22):4839-51.

联系方式

邮箱：yijiewang@sdnu.edu.cn

地址：山东省济南市长清区山东师范大学生命科学学院549