一、 简介

马文青，女，汉族，理学博士，副教授，1991年11月生。2020年6月毕业于山东师范大学细胞生物学专业。目前于反刍动物疾病研究中心动物病毒学创新团队从事科研工作。主要研究病毒与宿主基因互作的相关研究工作，以第一作者及并列第一作者在 Autophagy、Cellular & Molecular Immunology、Cell Death & Disease、PLOS Pathogens 等国际杂志发表 SCI 论文 15 篇；主持国家自然科学基金青年基金项目1项，山东省自然基金青年项目1项；获得山东省科技进步一等奖1项；申报国家发明专利1项；制定山东省地方标准1项；在教学中承担本科生专业课程《生物伦理学》《微生物学实验》等课程的教学任务。

二、 研究方向

病毒与宿主互作机制及抗病毒小分子药物研究。

三、 承担项目

1. Sec10通过降解STAT1抑制牛疱疹病毒1型诱导的I型干扰素反应的机制研究，国家自然科学基金（3220190148），主持，2013-2025，30万元。

2. Exo70促进牛传染性鼻气管炎病毒释放的机制研究（ZR2024QC063），主持，2025-2027，12万元

四、 教学科研成果（论文、专著、专利等）

代表性科研论文：

1. Wenqing Ma#, Yanan Xu#, Jie Yu, Fachao Sun, Xiao Yu, Luteng He, Yingying Li, Daniel Chang He, Hongmei Wang*, and Hongbin He*,. EXOC5/SEC10 attenuates antiviral IFN-I signaling by targeting STING1 for autophagic degradation. Autophagy. 2026, 22, 1639-1656.

2. Wang L#, Ma W#, Hou P, Jin R, Wei X, Li X, et al. Sec8: a novel positive regulator of RIG-I in anti-RNA viral defense. Cell death & disease 2026, 17(1): 165.

3. Fachao Sun#; Wenqing Ma#; Yanan Xu; Luteng He; Xiao Yu; Xingyu Li; Yingying Li; Daniel Chang He; Hongmei Wang*; Hongbin He*. Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation. PLOS Pathogens. 2025, 21(9):e1013472.

4. Lin Wang#; Peili Hou#; Wenqing Ma#; Rong Jin; Xinxin Wei; Xingyu Li; Hongbin He*; Hongmei Wang*. Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis. Autophgy. 2025, 21(12):2578-2596.

5. Ma W, Yu X, Xu Y, Sun F, Zhao M, Wang X, et al. SEC10 suppresses KLF15-mediated transcriptional activation of JAK1 and promotes BoHV-1 replication. Veterinary microbiology 2026, 316: 111004.

6. Yanan Xu#; Wenqing Ma#; Hongbin He*; Hongmei Wang*. BoHV-1 UL3 inhibits RLR signaling response by degrading MAVS. Veterinary Microbiology. 2026, 312: 110791.

7. Xiaoting Zhang#; Wenqing Ma#; Hongbin He*; Hongmei Wang*. Sec6 suppresses BoHV-1-triggered innate immunity through NDP52-mediated autophagic degradation of STING. Veterinary Microbiology. 2026, 312: 110836.

8. Xiaoting Zhang#; Wenqing Ma#; Hongbin He*; Hongmei Wang*. Sec6 suppresses BEFV-triggered type I IFN responses by promoting P62-mediated MAVS degradation. Veterinary Microbiology. 2025, 308:110658.

9. Fachao Sun#; Wenqing Ma#; Hongmei Wang*; Hongbin He*. Tegument protein UL3 of bovine herpesvirus 1 suppresses antiviral IFN-I signaling by targeting STING for autophagic degradation. Veterinary Microbiology. 2024, 291:110031.

10. Xingyu Li^#, Peili Hou^#, Wenqing Ma^#, Xuefeng Wang^#, Hongmei Wang^*, Zhangping Yu, Huasong Chang, Tiecheng Wang, Song Jin, Xue Wang, Wenqi Wang, Yudong Zhao, Yong Zhao, Chunqing Xu, Xiaomei Ma, Yuwei Gao^* and Hongbin He^*,SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy, Cell Mol Immunol. 2022 Jan; 19(1): 67–78.

11. Wenqing Ma; Hongmei Wang*; Hongbin He*; Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41, Veterinary Microbiology, 2020, 245: 108709.

12. Wenqing Ma; Hongmei Wang*; Hongbin He*; Bovine herpesvirus 1 tegument protein UL41 suppresses antiviral innate immune response via directly targeting STAT1, Veterinary Microbiology, 2019, 239: 108494.

13. Wenqing Ma; Hongbin He*; Hongmei Wang*. Oncolytic herpes simplex virus and immunotherapy. BMC Immunol; 2018, 19(1):40.

14. Wang S, Ma X, Guo J, Li F, Chen T, Ma W, He C, Wang H, He H*. DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway. Virulence. 2022;13(1):514-529.

15. Zhao W, Hou P, Ma W, Jiang C, Wang H*, He H*, Bta-miR-101 suppresses BEFV replication via targeting NKRF. Vet Microbiol. 2021 Aug;259:109127

16. Miao Yin#*; Wenqing Ma#; Liguo An; Cortactin in cancer cell migration and invasion, Oncotarget, 2017, 8(50): 88232-88243.

17. Wenqing Ma; Yu Wang; Xiaomeng Yao; Zijian Xu; Liguo An; Miao Yin*; The role of Exo70 in vascular smooth muscle cell migration, Cellular & Molecular Biology Letters, 2016, 21: 20.

地方标准及专利

1.何洪彬、赵贵民、王洪梅、侯佩莉、马文青、何成强、程凯慧、杨宏军、张亮、解晓莉. 牛羊养殖场气溶胶布鲁氏菌荧光定量PCR鉴别检测技术规程. DB37/T 3625—2019. 2019- 07-23发布。

2. 王洪梅，马文青，何洪彬，和鲁腾，何畅。Endosidin-2在制备抗病毒药物中的应用，国家发明专利，专利申请号：CN202311487171.7，申请日期：2023-11-08。

五、 获奖

1. 牛三种重要传染病防控关键技术研发与示范应用，山东省科技进步一等奖，第一位，证书号：JB2021-1-24-R11，授奖日期：2021-12-21。