一、 简介

陈蕾，女，博士，教授，博士生导师。主持国家重点研发计划、国家重点研发计划子课题、国家自然科学基金、山东省自然科学基金青年基金项目（A 类）等国家和省部级重点项目，相关研究成果授权发明专利9 项，制定山东省地方标准6 项。以第一或通讯作者在 Chemical Engineering Journal、Biosensors and Bioelectronics等国际权威杂志上发表学术论文30余篇。以第一完成人获山东省科技进步二等奖1 项获“山东战疫最美青年”“新时代齐鲁最美青年”和“齐鲁最美职工”、山东师范大学“杰出青年”、山东师范大学“优秀党员”等荣誉称号。

Email:chenlei@sdnu.edu.cn

二、 研究方向

1.病原与宿主互作机制

2.用于病原及疾病标志物检测的新型生物传感技术研究

三、 承担项目

1. 国家重点研发计划重点专项项目 在研

2. 国家重点研发计划子课题 在研

3. 山东省自然科学基金青年基金（A类）在研

4.高端外国专家引进计划 结题

5. 国家自然科学基金 结题

四、 教学科研成果（论文、专著、专利等）

1. 论文

(1) Mengqi Zhao ^a,1,Qianmin Zhuang ^a,1,Xiaowen Wang ^a,1,Jiansen Gong ^b,2,Lei Chen ^a, * . CRISPR/Cas12a-based dual intelligent sensors for home pet detection via personal glucose meters. Anal Chim Acta, 2026 Oct 22;1420:345935.

(2) Xueqian Zhang ^a,1, Kaini Zhang ^a,1, Yongdong Fu ^b, Shanji Fu ^c, Lulu Zhang ^b,*, Lei Chen ^a,*. A CRISPR/Cas12a-mediated BioLayer interferometry biosensor for rapid and specific detection of HPV16 and HPV18. Microchemical Journal, 2026 Jan;221: 116870.

(3) Xiaowen Wang ^a,1, Jinlong Gu ^a,1, Yujie Liu ^b, Qianmin Zhuang ^a, Meng Tian ^c, Lei Chen ^a, *. A CRISPR-graphene field-effect transistor sensor for ultrasensitive detection of live methicillin-resistant Staphylococcus aureus. Microchemical Journal, 2026 May;224: 117618.

(4) Lei Chen ^a,1, Shanshan Zhao ^b,1, Xiaokun Li ^a, Xilong Wang ^a, Guanliu Yu ^a, *. Synergistic effects of microplastics and bioaerosols: emerging trends in urban air pollution complexification and public health implications. Environmental Research, 2025 Dec 1;286 (Pt 1): 122808-122808.

(5) Lei Chen ^a,1, Qiaoli Zhang ^a,1, Wenbo Sun ^b, Michael G. Mauk ^c, Qingmei Li ^{d, *}. Detection method for identifying duck hepatitis A virus 3 virulent and attenuated strains based on RPA CRISPR single-base recognition system. Poult Sci. 2025 May 1;104(8):105241.

(6) Lei Chen*, Xiaowen Wang, Michael G. Mauk, Xuehui Pang*. Ultrasensitive rapid quantitative CRISPR-based detection of cervical cancer tumor marker proteins SCCA and CEA. Chemical Engineering Journal, 2025. 512: p. 162465.

(7) Kaini Zhang, Qingmei Li, Kun Wang, Qiaoli Zhang, Chengkun Ma, Guiwen Yang, Yanxia Xie, Michael G. Mauk, Shanji Fu, * and Lei Chen*.RPA-CRISPR-Cas-Mediated Dual Lateral Flow Assay for the Point-of-Care Testing of HPV16 and HPV18. Bioconjugate Chemistry.2024 Nov 20;35(11):1797-1804.

(8) Qiaoli Zhang¹, Guanliu Yu ¹, Xinli Ding, Kaini Zhang, Wenbo Sun, Qingmei Li, Yunpeng Yi, Jianhua Wang, Xuehui Pang, Lei Chen*. A rapid simultaneous detection of duck hepatitis A virus 3 and novel duck reovirus based on RPA CRISPR Cas12a/Cas13a. Int J Biol Macromol. 2024 Aug;274(Pt 1):133246.

(9) Yujie Liu, Guanliu Yu, Hongkun Liang, Wenbo Sun, Lulu Zhang, Michael G Mauk, Hua Li, Lei Chen*. Detection and identification of SARS-CoV-2 and influenza a based on microfluidic technology. Anal Methods. 2024 Jul 11;16(27):4582-4589.

(10) Lei Chen ^a， Zhicheng Song ^a , Xintian Zhou , Guiwen Yang ^a , Guanliu Yu ^a,*.Pathogenic bacteria and fungi in bioaerosols from specialized hospitals in Shandong province, East China. Environmental Pollution. 2023 Nov. 341:122922.

(11) Linyi Bai, Guanliu Yu, Yujie Liu, Muhammad Aizaz, Guiwen Yang, Lei Chen*. Common carp intelectin 3 (cITLN3) plays a role in the innate immune response. Fish & shellfish immunology. 2023 Oct: 141:109057.

(12) Hua Wang, Yang Sun, Yuan Zhou, Yujie Liu, Shuo Chen, Wenbo Sun, Zidong Zhang, Junqing Guo, Cheng Yang, Zhengping Li, Lei Chen*. Unamplified system for sensitive and typing detection of ASFV by the cascade platform that CRISPR-Cas12a combined with graphene field-effect transistor. Biosens Bioelectron. 2023 Aug 25; 240:115637. doi: 10.1016/j.bios.2023.115637.

2. 专利

(1) 陈蕾，王梓涵，于观留，刘欣，李晓坤，王禧龙，李华，杨桂文，张楚博，一种畜禽养殖舍环境微生物气溶胶采样装置，ZL202511143107.6

(2) 孙文博，吴家强，陈智，高蕾，陈蕾，刘清政，刘国宪，郑乾坤,李敏，黄耀伟，于江，任素芳，张玉玉，刘飞，李建达，一种基于重组酶恒温扩增的快速检测核酸的微流控芯片试剂盒，ZL202410066619.6

(3) 孙文博, 吴家强, 陈智, 郑乾坤, 李敏, 邱宪波, 张璐璐, 刘国宪, 杜以军, 丛晓燕, 陈蕾, 于江, 李俊, 时建立, 郭立辉, 任素芳，猪内脏组织活体采样并进行核酸提取的装置，ZL201811145454.2

五、 获奖

山东省科学技术进步奖二等奖 首位