一、 个人简介

常化松，男，博士，硕士生导师。2024年6月获山东师范大学理学博士学位，同年10月入职山东师范大学生命科学学院，现于动物病毒学团队从事科研工作。近年来，以第一作者或并列第一作者在Cellular & Molecular Immunology、Communications Biology、PLoS Pathogens和Journal of Virology等期刊上发表SCI论文多篇。主持国家自然科学基金青年项目1项。

二、研究方向

天然免疫系统是宿主抵御病原体的第一道防线，本课题组聚焦动物病毒与宿主抗病毒天然免疫的互作机制的研究，具体研究包括：（1）病毒入侵机制：揭示病毒入侵宿主的关键分子事件及其调控机制；（2）病毒复制调控：运用高通量测序等技术系统鉴定调控病毒复制的宿主因子并阐明其作用机制，为抗病毒药物研发提供新靶点和理论支撑。

三、承担项目

1. 国家自然科学基金青年项目（C类）（32604548），2027.01-2029.12，30万，主持。

2. 山东省博士后创新项目(一等资助)（SDCX-ZG-202501028），2025.07-2027.06，8万，主持。

四、代表性科研成果

1. Huasong Chang^#, Peili Hou^#, Xuefeng Wang^#, Aibiao Xiang, Hao Wu, Wenjing Qi, Rukun Yang, Xue Wang, Xingyu Li, Wenqi He, Guimin Zhao, Weiyang Sun, Tiecheng Wang, Daniel Chang He, Hongmei Wang^*, Yuwei Gao^*, Hongbin He^*. CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation. Cellular & molecular immunology, 2023, 20(12), 1457–1471.

2. Huasong Chang, Rukun Yang, Wenjing Qi, Peili Hou, Aibiao Xiang, Xiaoyu Liu, Ran Kang, Hongmei Wang^*, Hongbin He^*. Inhibition of STING-mediated antiviral innate immunity activation by CD97 via modulation of ER-phagy, Communications Biology, 2025, 9(1): 109.

3. Huasong Chang^#, Wenjing Qi^#, Rukun Yang, Peili Hou, Ran Kang, Xiaoyu Liu, Yingying Li, Hongmei Wang^*, Hongbin He^*. The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway, PLoS Pathogens, 2026, 22(3): e1014032.

4. Huasong Chang^#, Hao Wu^#, Peili Ho, Muhammad Aizaz, Rukun Yang, Aibiao Xiang, Wenjing Qi, Hongbin He^*, Hongmei Wang^*. DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε. Journal of virology, 2023, 97(12), e0150123.

5. Huasong Chang^#, Haili Cha^#, Rukun Yang^#, Wenjing Qi, Hongmei Wang^*, Hongbin He^*. TEX264 suppresses antiviral immune response by promoting STING degradation through ER-phagy. The FEBS journal, 2026, 10.1111.

6. Huasong Chang^#, Ran Kang^#, Rukun Yang, Wenjing Qi, Hongmei Wang^*, Hongbin He^*. Sanguinarine inhibits bovine parainfluenza virus type 3 replication through CD97 suppression, Veterinary Microbiology, 2025, 311: 110776.

7. Wenjing Qi^#, Huasong Chang^#, Ran Kang, Hongmei Wang^*, Hongbin He^*. Viral infection-induced CD97 upregulation facilitates viral invasion by interacting with viral proteins. Veterinary microbiology, 2025, 308, 110660.

8. 陈义；常化松；孙明辉；王琦；马雪娇；陈春雷。一种牙髓干细胞冻存保护液和牙髓干细胞冻存方法，国家发明专利，专利授权号：CN112998008B，授权日期：2021-12-21。

五、联系方式

邮箱：changhuasong@sdnu.edu.cn